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Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG

The genetically encoded photosensitizer miniSOG (mini Singlet Oxygen Generator) can be used to kill cells in C. elegans. miniSOG generates the reactive oxygen species (ROS) singlet oxygen after illumination with blue light. Illumination of neurons expressing miniSOG targeted to the outer mitochondri...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Xu, Suhong, Chisholm, Andrew D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748272/
https://ncbi.nlm.nih.gov/pubmed/26861262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21271
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