The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency

4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N-(deoxyguanosin-8-yl)-4AQO, 3-(desoxyguan...

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Detalhes bibliográficos
Publicado no:Mutagenesis
Principais autores: Brüsehafer, Katja, Manshian, Bella B., Doherty, Ann T., Zaïr, Zoulikha M., Johnson, George E., Doak, Shareen H., Jenkins, Gareth J. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748179/
https://ncbi.nlm.nih.gov/pubmed/26362870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gev069
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