Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-κB/COX-2 signaling in human aortic endothelial cells

Adiponectin (Ad) is an insulin-sensitizing adipocytokine with anti-inflammatory and vasoprotective properties. Cleavage of native full-length Ad (fAd) by elastases from activated monocytes generates globular Ad (gAd). Increased gAd levels are observed in the proximity of atherosclerotic lesions, but...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Addabbo, Francesco, Nacci, Carmela, Benedictis, Leonarda De, Leo, Valentina, Tarquinio, Mariela, Quon, Michael J., Montagnani, Monica
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747914/
https://ncbi.nlm.nih.gov/pubmed/21900123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00208.2011
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