Mechanical Stretch Inhibits MicroRNA499 via p53 to Regulate Calcineurin-A Expression in Rat Cardiomyocytes

BACKGROUND: MicroRNAs play an important role in cardiac remodeling. MicroRNA 499 (miR499) is highly enriched in cardiomyocytes and targets the gene for Calcineurin A (CnA), which is associated with mitochondrial fission and apoptosis. The mechanism regulating miR499 in stretched cardiomyocytes and i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chua, Su-Kiat, Wang, Bao-Wei, Lien, Li-Ming, Lo, Huey-Ming, Chiu, Chiung-Zuan, Shyu, Kou-Gi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747570/
https://ncbi.nlm.nih.gov/pubmed/26859150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148683
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