Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer

Dual-specificity phosphatases (DUSPs) dephosphorylate threonine/serine and tyrosine residues on their substrates. Here we show that DUSP1, DUSP4, and DUSP6 are involved in epithelial-to-mesenchymal transition (EMT) and breast cancer stem cell (CSC) regulation. DUSP1, DUSP4, and DUSP6 are induced dur...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Boulding, Tara, Wu, Fan, McCuaig, Robert, Dunn, Jennifer, Sutton, Christopher R., Hardy, Kristine, Tu, Wenjuan, Bullman, Amanda, Yip, Desmond, Dahlstrom, Jane E., Rao, Sudha
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747493/
https://ncbi.nlm.nih.gov/pubmed/26859151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148065
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