A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

BACKGROUND: The genetic variation underlying atorvastatin (ATV) pharmacokinetics was evaluated in a Mexican population. Aims of this study were: 1) to reveal the frequency of 87 polymorphisms in 36 genes related to drug metabolism in healthy Mexican volunteers, 2) to evaluate the impact of these pol...

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Udgivet i:BMC Cancer
Main Authors: León-Cachón, Rafael B. R., Ascacio-Martínez, Jorge A., Gamino-Peña, María E., Cerda-Flores, Ricardo M., Meester, Irene, Gallardo-Blanco, Hugo L., Gómez-Silva, Magdalena, Piñeyro-Garza, Everardo, Barrera-Saldaña, Hugo A.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746878/
https://ncbi.nlm.nih.gov/pubmed/26857559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2062-2
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