Attenuation of ligand-induced activation of angiotensin II type 1 receptor signaling by the type 2 receptor via protein kinase C

Angiotensin II (AII) type 2 receptor (AT2R) negatively regulates type 1 receptor (AT1R) signaling. However, the precise molecular mechanism of AT2R-mediated AT1R inhibition remains poorly understood. Here, we characterized the local and functional interaction of AT2R with AT1R. AT2R colocalized and...

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Publicado no:Sci Rep
Main Authors: Inuzuka, Takayuki, Fujioka, Yoichiro, Tsuda, Masumi, Fujioka, Mari, Satoh, Aya O., Horiuchi, Kosui, Nishide, Shinya, Nanbo, Asuka, Tanaka, Shinya, Ohba, Yusuke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746669/
https://ncbi.nlm.nih.gov/pubmed/26857745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21613
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