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Mutation of C. elegans demethylase spr-5 extends transgenerational longevity
Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modif...
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| Vydáno v: | Cell Res |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746603/ https://ncbi.nlm.nih.gov/pubmed/26691751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.148 |
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