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Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats
G protein–coupled receptor 109A (GPR109A) activation by its ligand nicotinic acid (NA) in immune cells increases Ca(2+) levels, and Ca(2+) induces glutamate release and oxidative stress in central blood pressure (BP)-regulating nuclei, for example, the rostral ventrolateral medulla (RVLM), leading t...
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| Publicado no: | J Pharmacol Exp Ther |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746491/ https://ncbi.nlm.nih.gov/pubmed/26621144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229146 |
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