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HIV-1 gp120Bal down-regulates phosphorylated NMDA receptor subunit 1 in cortical neurons via activation of glutamate and chemokine receptors

HIV-1 envelope glycoprotein gp120 (gp120) is a major virulence protein implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Although gp120 has been suggested to cause synaptic and neuronal injuries by disrupting NMDA receptor (NMDAR) function, the underlying mechanism is...

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Publicado en:J Neuroimmune Pharmacol
Main Authors: Ru, Wenjuan, Tang, Shao-Jun
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746099/
https://ncbi.nlm.nih.gov/pubmed/26582091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-015-9644-7
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