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Genetic variation and the de novo assembly of human genomes

The discovery of genetic variation and the assembly of genome sequences are both inextricably linked to advances in DNA-sequencing technology. Short-read massively parallel sequencing has revolutionized our ability to discover genetic variation but is insufficient to generate high-quality genome ass...

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Bibliografske podrobnosti
izdano v:Nat Rev Genet
Main Authors: Chaisson, Mark J. P., Wilson, Richard K., Eichler, Evan E.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745987/
https://ncbi.nlm.nih.gov/pubmed/26442640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3933
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