Bacteriophage administration significantly reduces Shigella colonization and shedding by Shigella-challenged mice without deleterious side effects and distortions in the gut microbiota

We used a mouse model to establish safety and efficacy of a bacteriophage cocktail, ShigActive™, in reducing fecal Shigella counts after oral challenge with a susceptible strain. Groups of inbred C57BL/6J mice challenged with Shigella sonnei strain S43-NalAcR were treated with a phage cocktail (Shig...

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Detalhes bibliográficos
Publicado no:Bacteriophage
Main Authors: Mai, Volker, Ukhanova, Maria, Reinhard, Mary K, Li, Manrong, Sulakvelidze, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745833/
https://ncbi.nlm.nih.gov/pubmed/26909243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21597081.2015.1088124
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