Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control

Genome-wide association studies (GWAS) have identified over 40 type 1 diabetes risk loci. The clinical impact of these loci on β-cell function during disease progression is unknown. We aimed at testing whether a genetic risk score could predict glycemic control and residual β-cell function in type 1...

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Detalhes bibliográficos
Publicado no:J Diabetes Res
Main Authors: Brorsson, Caroline A., Nielsen, Lotte B., Andersen, Marie Louise, Kaur, Simranjeet, Bergholdt, Regine, Hansen, Lars, Mortensen, Henrik B., Pociot, Flemming, Størling, Joachim, Hvidoere Study Group on Childhood Diabetes
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745814/
https://ncbi.nlm.nih.gov/pubmed/26904692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9570424
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