Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

The immunoglobulin heavy-chain variable region (IGHV) mutational status is a strong determinant of remission duration in chronic lymphocytic leukemia (CLL). The aim of this work was to compare the multidrug resistance (MDR) signature of IGHV mutated and unmutated CLL cells, identifying biochemical a...

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Vydáno v:Oncotarget
Hlavní autoři: Rigoni, Micol, Riganti, Chiara, Vitale, Candida, Griggio, Valentina, Campia, Ivana, Robino, Marta, Foglietta, Myriam, Castella, Barbara, Sciancalepore, Patrizia, Buondonno, Ilaria, Drandi, Daniela, Ladetto, Marco, Boccadoro, Mario, Massaia, Massimo, Coscia, Marta
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745766/
https://ncbi.nlm.nih.gov/pubmed/26284584
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