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Differential targeting of the cyclin-dependent kinase inhibitor, p21(CIP1/WAF1), by chelators with anti-proliferative activity in a range of tumor cell-types
Chelators such as 2-hydroxy-1-napthylaldehyde isonicotinoyl hydrazone (311) and di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) target tumor cell iron pools and inhibit proliferation. These agents also modulate multiple targets, one of which is the cyclin-dependent kinase inhibitor, p21...
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| Udgivet i: | Oncotarget |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4745756/ https://ncbi.nlm.nih.gov/pubmed/26335183 |
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