A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation

Interleukin (IL)-12 and IL-23 respectively driving polarization of T helper (Th) 1 and Th17 cells has been strongly implicated in the pathogenesis of both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In this study, we first constructed, expressed and purified a novel...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guo, Wei, Wang, Chen, Wang, Xin, Luo, Cheng, Yu, Dongmei, Wang, Yuheng, Chen, Yucong, Lei, Wen, Gao, Xiangdong, Yao, Wenbing
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper: Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745676/
https://ncbi.nlm.nih.gov/pubmed/26384304
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