The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1

Progranulin (PGRN) is a recently identified adipokine that is supposed to have anti-inflammatory actions. The proinflammatory cytokine interleukin-1β (IL1β) stimulates several mediators of cartilage degradation. Toll like receptor-4 (TLR4) can bind to various damage-associated molecular patterns, le...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Abella, Vanessa, Scotece, Morena, Conde, Javier, López, Verónica, Pirozzi, Claudio, Pino, Jesús, Gómez, Rodolfo, Lago, Francisca, González-Gay, Miguel Ángel, Gualillo, Oreste
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745010/
https://ncbi.nlm.nih.gov/pubmed/26853108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20356
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky