P(i) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5)

mRNA export from the nucleus depends on the ATPase activity of the DEAD-box protein Dbp5/DDX19. Although Dbp5 has measurable ATPase activity alone, several regulatory factors (e.g., RNA, nucleoporin proteins, and the endogenous small molecule InsP(6)) modulate catalytic activity in vitro and in vivo...

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Publicado en:J Mol Biol
Main Authors: Wong, Emily V., Cao, Wenxiang, Vörös, Judit, Merchant, Monique, Modis, Yorgo, Hackney, David D., Montpetit, Ben, De La Cruz, Enrique M.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744555/
https://ncbi.nlm.nih.gov/pubmed/26730886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.12.018
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