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Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats
OBJECTIVE(S): Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test. MATERIALS AND METHODS: Orexin-A...
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| 出版年: | Iran J Basic Med Sci |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Mashhad University of Medical Sciences
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744357/ https://ncbi.nlm.nih.gov/pubmed/26877847 |
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