Schwann Cell Expression of PLP1 but Not DM20 Is Necessary to Prevent Neuropathy

Proteolipid protein (PLP1) and its alternatively spliced isoform, DM20, are the major myelin proteins in the CNS, but are also expressed in the PNS. The proteins have an identical sequence except for 35 amino acids in PLP1 (the PLP1-specific domain) not present in DM20. Mutations of PLP1/DM20 cause...

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Veröffentlicht in:Ann Neurol
Hauptverfasser: Shy, Michael E., Hobson, Grace, Jain, Manisha, Boespflug-Tanguy, Odile, Garbern, James, Sperle, Karen, Li, Wen, Gow, Alex, Rodriguez, Diana, Bertini, Enrico, Mancias, Pedro, Krajewski, Karen, Lewis, Richard, Kamholz, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744322/
https://ncbi.nlm.nih.gov/pubmed/12601703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.10466
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