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Aquaporin-4 Regulates the Velocity and Frequency of Cortical Spreading Depression in Mice

The astrocyte water channel aquaporin-4 (AQP4) regulates extracellular space (ECS) K(+) concentration ([K(+)](e)) and volume dynamics following neuronal activation. Here, we investigated how AQP4-mediated changes in [K(+)](e) and ECS volume affect the velocity, frequency and amplitude of cortical sp...

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Detalles Bibliográficos
Publicado en:Glia
Main Authors: Yao, Xiaoming, Smith, Alex J., Jin, Byung-Ju, Zador, Zsolt, Manley, Geoffrey T., Verkman, A.S.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743984/
https://ncbi.nlm.nih.gov/pubmed/25944186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22853
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