Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes

Obesity, and the associated disturbed glycerolipid/fatty acid (GL/FA) cycle, contribute to insulin resistance, islet β-cell failure, and type 2 diabetes. Flux through the GL/FA cycle is regulated by the availability of glycerol-3-phosphate (Gro3P) and fatty acyl-CoA. We describe here a mammalian Gro...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Mugabo, Yves, Zhao, Shangang, Seifried, Annegrit, Gezzar, Sari, Al-Mass, Anfal, Zhang, Dongwei, Lamontagne, Julien, Attane, Camille, Poursharifi, Pegah, Iglesias, José, Joly, Erik, Peyot, Marie-Line, Gohla, Antje, Madiraju, S. R. Murthy, Prentki, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743820/
https://ncbi.nlm.nih.gov/pubmed/26755581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514375113
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