Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity

The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity of this remarkable family of light-activated ion channels. The first generation of chloride-conducting channelrhodopsins, guided in part by development of a structure-informed e...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Berndt, Andre, Lee, Soo Yeun, Wietek, Jonas, Ramakrishnan, Charu, Steinberg, Elizabeth E., Rashid, Asim J., Kim, Hoseok, Park, Sungmo, Santoro, Adam, Frankland, Paul W., Iyer, Shrivats M., Pak, Sally, Ährlund-Richter, Sofie, Delp, Scott L., Malenka, Robert C., Josselyn, Sheena A., Carlén, Marie, Hegemann, Peter, Deisseroth, Karl
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743797/
https://ncbi.nlm.nih.gov/pubmed/26699459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523341113
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