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PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease

Mitochondrial anomalies have been previously reported in patients′ brain and peripheral tissue, suggesting their relevance in sporadic Alzheimer's disease (AD). The present work evaluates mitochondrial function and recycling in human fibroblasts and brain biopsies. Functional studies using pati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Martín-Maestro, Patricia, Gargini, Ricardo, Perry, George, Avila, Jesús, García-Escudero, Vega
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743695/
https://ncbi.nlm.nih.gov/pubmed/26721933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv616
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