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FIG4 regulates lysosome membrane homeostasis independent of phosphatase function
FIG4 is a phosphoinositide phosphatase that is mutated in several diseases including Charcot-Marie-Tooth Disease 4J (CMT4J) and Yunis-Varon syndrome (YVS). To investigate the mechanism of disease pathogenesis, we generated Drosophila models of FIG4-related diseases. Fig4 null mutant animals are viab...
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Vydáno v: | Hum Mol Genet |
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Hlavní autoři: | , , , |
Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
Oxford University Press
2016
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4743688/ https://ncbi.nlm.nih.gov/pubmed/26662798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv505 |
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