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FIG4 regulates lysosome membrane homeostasis independent of phosphatase function

FIG4 is a phosphoinositide phosphatase that is mutated in several diseases including Charcot-Marie-Tooth Disease 4J (CMT4J) and Yunis-Varon syndrome (YVS). To investigate the mechanism of disease pathogenesis, we generated Drosophila models of FIG4-related diseases. Fig4 null mutant animals are viab...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Bharadwaj, Rajnish, Cunningham, Kathleen M., Zhang, Ke, Lloyd, Thomas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743688/
https://ncbi.nlm.nih.gov/pubmed/26662798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv505
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