Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase.

A series of potent and highly selective time-dependent monocyclic beta-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is described. The intrinsic potency of these compounds, as exemplified by L-680,833 (k(inactivation)/K(i) of 622,000 M-1.s-1), is reflected at t...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Doherty, J B, Shah, S K, Finke, P E, Dorn, C P, Hagmann, W K, Hale, J J, Kissinger, A L, Thompson, K R, Brause, K, Chandler, G O
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47431/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8378355/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.18.8727
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