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Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease

BACKGROUND: Lower leg ischemia, myopathy, and limb dysfunction are distinguishing features of peripheral artery disease (PAD). The myopathy of PAD is characterized by myofiber degeneration in association with extracellular matrix expansion, and increased expression of transforming growth factor-beta...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Ha, Duy M., Carpenter, Lauren C., Koutakis, Panagiotis, Swanson, Stanley A., Zhu, Zhen, Hanna, Mina, DeSpiegelaere, Holly K., Pipinos, Iraklis I., Casale, George P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743093/
https://ncbi.nlm.nih.gov/pubmed/26847457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0790-3
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