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ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

Mutations in FUS cause amyotrophic lateral sclerosis (ALS), including some of the most aggressive, juvenile-onset forms of the disease. FUS loss-of-function and toxic gain-of-function mechanisms have been proposed to explain how mutant FUS leads to motor neuron degeneration, but neither has been fir...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sharma, Aarti, Lyashchenko, Alexander K., Lu, Lei, Nasrabady, Sara Ebrahimi, Elmaleh, Margot, Mendelsohn, Monica, Nemes, Adriana, Tapia, Juan Carlos, Mentis, George Z., Shneider, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742863/
https://ncbi.nlm.nih.gov/pubmed/26842965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10465
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