Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in NAFLD by integrating global transcriptomic data, from human liver biopsies, and metabolic flux data, measured across the...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Hyötyläinen, Tuulia, Jerby, Livnat, Petäjä, Elina M., Mattila, Ismo, Jäntti, Sirkku, Auvinen, Petri, Gastaldelli, Amalia, Yki-Järvinen, Hannele, Ruppin, Eytan, Orešič, Matej
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742839/
https://ncbi.nlm.nih.gov/pubmed/26839171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9994
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