Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation.

Lesions of the cholinergic nucleus basalis of Meynert elevate the ex vivo synthesis of beta amyloid precursor protein (beta-APP) in the cerebral cortex, a major projection region. We have found that this elevation is reflected by increased levels of beta-APP mRNA. The induction is rapid (occurring 6...

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Autors principals: Wallace, W, Ahlers, S T, Gotlib, J, Bragin, V, Sugar, J, Gluck, R, Shea, P A, Davis, K L, Haroutunian, V
Format: Artigo
Idioma:Inglês
Publicat: 1993
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC47428/
https://ncbi.nlm.nih.gov/pubmed/8378353
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