Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Neutrophil extracellular traps (NETs) are implicated in autoimmunity but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes, inducers of NETosis, require mitochondrial ROS for maximal NET stimulation. During this process, mitochondria be...

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Pubblicato in:Nat Med
Autori principali: Lood, Christian, Blanco, Luz P., Purmalek, Monica M., Carmona-Rivera, Carmelo, De Ravin, Suk S., Smith, Carolyne K., Malech, Harry L., Ledbetter, Jeffrey A., Elkon, Keith B., Kaplan, Mariana J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742415/
https://ncbi.nlm.nih.gov/pubmed/26779811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4027
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