Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking

The NS5B polymerase is one of the most attractive targets for developing new drugs to block Hepatitis C virus (HCV) infection. We describe the discovery of novel potent HCV NS5B polymerase inhibitors by employing a virtual screening (VS) approach, which is based on random forest (RB-VS), e-pharmacop...

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Bibliographic Details
Published in:PLoS One
Main Authors: Wei, Yu, Li, Jinlong, Qing, Jie, Huang, Mingjie, Wu, Ming, Gao, Fenghua, Li, Dongmei, Hong, Zhangyong, Kong, Lingbao, Huang, Weiqiang, Lin, Jianping
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742222/
https://ncbi.nlm.nih.gov/pubmed/26845440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148181
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