Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo

Hypoxic microenvironment is a common situation in solid tumors. Carbonic anhydrase IX (CA9) is one of the reliable cellular biomarkers of hypoxia. The role of CA9 in colorectal cancer (CRC) remains to be clarified. CA9 inhibitor such as sulfonamides is known to block CA9 activation and reduce tumor...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guan, Siao-Syun, Cheng, Chun-Chia, Ho, Ai-Sheng, Wang, Chia-Chi, Luo, Tsai-Yueh, Liao, Tse-Zung, Chang, Jungshan, Wu, Cheng-Tien, Liu, Shing-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742167/
https://ncbi.nlm.nih.gov/pubmed/26447758
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