Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney

Here we showed that dietary NiCl(2) in excess of 300 mg/kg caused the G(2)/M cell cycle arrest and the reduction of cell proportion at S phase. The G(2)/M cell cycle arrest was accompanied by up-regulation of phosphorylated ataxia telangiectasia mutated (p-ATM), p53, p-Chk1, p-Chk2, p21 protein expr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guo, Hongrui, Cui, Hengmin, Peng, Xi, Fang, Jing, Zuo, Zhicai, Deng, Junliang, Wang, Xun, Wu, Bangyuan, Chen, Kejie, Deng, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742154/
https://ncbi.nlm.nih.gov/pubmed/26440151
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