Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling

ADAM10 (A Disintegrin and Metalloprotease Domain 10) affects the pathophysiology of various cancers, and we had shown that inhibition of ADAM10 sensitizes pancreatic cancer cells to gemcitabine. ADAM10 is activated in response to calcium influx, and here we examined if calcium channel blockers (CCB)...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Woods, Neha, Trevino, Jose, Coppola, Domenico, Chellappan, Srikumar, Yang, Shengyu, Padmanabhan, Jaya
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742152/
https://ncbi.nlm.nih.gov/pubmed/26440150
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