Age-dependent uncoupling of mitochondria from Ca(2+) release units in skeletal muscle

Calcium release units (CRUs) and mitochondria control myoplasmic [Ca(2+)] levels and ATP production in muscle, respectively. We recently reported that these two organelles are structurally connected by tethers, which promote proximity and proper Ca(2+) signaling. Here we show that disposition, ultra...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Pietrangelo, Laura, D'Incecco, Alessandra, Ainbinder, Alina, Michelucci, Antonio, Kern, Helmut, Dirksen, Robert T., Boncompagni, Simona, Protasi, Feliciano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
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Research Paper: Gerotarget (Focus on Aging)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742110/
https://ncbi.nlm.nih.gov/pubmed/26485763
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