RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium

Intracellular amyloid beta (Aβ) has been implicated in neuronal cell death in Alzheimer's disease (AD). Intracellular Aβ also contributes to tight junction breakdown of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD). Although Aβ is predominantly secreted from neurona...

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Pubblicato in:Oncotarget
Autori principali: Park, Sung Wook, Kim, Jin Hyoung, Park, Sang Min, Moon, Minho, Lee, Kihwang, Park, Kyu Hyung, Park, Woo Jin, Kim, Jeong Hun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
Soggetti:
Research Paper: Gerotarget (Focus on Aging)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742103/
https://ncbi.nlm.nih.gov/pubmed/26431165
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