YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

Ewing sarcoma is an aggressive tumor of bone and soft tissue affecting predominantly children and young adults. Tumor-specific chromosomal translocations create EWS-FLI1 and similar aberrant ETS fusion proteins that drive sarcoma development in patients. ETS family fusion proteins and over-expressed...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Minas, Tsion Zewdu, Han, Jenny, Javaheri, Tahereh, Hong, Sung-Hyeok, Schlederer, Michaela, Saygideğer-Kont, Yasemin, Çelik, Haydar, Mueller, Kristina M., Temel, Idil, Özdemirli, Metin, Kovar, Heinrich, Erkizan, Hayriye Verda, Toretsky, Jeffrey, Kenner, Lukas, Moriggl, Richard, Üren, Aykut
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2015
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741957/
https://ncbi.nlm.nih.gov/pubmed/26462019
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