Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts

Anti-angiogenic therapy of solid tumors has until now failed to produce the long lasting clinical benefits desired, possibly due to the complexity of the neoangiogenic process. Indeed, a prominent role is played by “vasculogenic” or “vascular” mimicry (VM), a phenomenon in which aggressive cancer ce...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Orecchia, Paola, Conte, Romana, Balza, Enrica, Pietra, Gabriella, Mingari, Maria Cristina, Carnemolla, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741939/
https://ncbi.nlm.nih.gov/pubmed/26460958
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