Imaging of carbonic anhydrase IX with an (111)In-labeled dual-motif inhibitor

We developed a new scaffold for radionuclide-based imaging and therapy of clear cell renal cell carcinoma (ccRCC) targeting carbonic anhydrase IX (CAIX). Compound XYIMSR-01, a DOTA-conjugated, bivalent, low-molecular-weight ligand, has two moieties that target two separate sites on CAIX, imparting h...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Yang, Xing, Minn, Il, Rowe, Steven P., Banerjee, Sangeeta Ray, Gorin, Michael A., Brummet, Mary, Lee, Hye Soo, Koo, Soo Min, Sysa-Shah, Polina, Mease, Ronnie C., Nimmagadda, Sridhar, Allaf, Mohamad E., Pomper, Martin G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741798/
https://ncbi.nlm.nih.gov/pubmed/26418876
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