Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo

Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. In spite of advances in diagnosis and therapy, the prognosis of patients with GBM has remained dismal. The fast recurrence and multi-drug resistance are some of the key challenges in combating brain tumors. Glioma stem cel...

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Vydáno v:Oncotarget
Hlavní autoři: Yu, Zhiyun, Zhao, Gang, Xie, Guifang, Zhao, Liyan, Chen, Yong, Yu, Hongquan, Zhang, Zhonghua, Li, Cai, Li, Yunqian
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741740/
https://ncbi.nlm.nih.gov/pubmed/26431379
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