PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis. It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling pathways are aberrantly reactivated in pancreatic CSCs. Here, we examined the efficacy of combining NVP-LDE-225 (PI3K/...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sharma, Narinder, Nanta, Rajesh, Sharma, Jay, Gunewardena, Sumedha, Singh, Karan P., Shankar, Sharmila, Srivastava, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741658/
https://ncbi.nlm.nih.gov/pubmed/26451606
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