A cytoplasmic C-terminal fragment of syndecan-1 is generated by sequential proteolysis and antagonizes syndecan-1 dependent lung tumor cell migration

Syndecan-1 is a surface expressed heparan sulphate proteoglycan, which is upregulated by several tumor types and involved in tumor cell migration and metastasis. Syndecan-1 is shed from the cell surface and the remaining transmembrane fragment undergoes intramembrane proteolysis by γ-secretase. We h...

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Udgivet i:Oncotarget
Main Authors: Pasqualon, Tobias, Pruessmeyer, Jessica, Jankowski, Vera, Babendreyer, Aaron, Groth, Esther, Schumacher, Julian, Koenen, Andrea, Weidenfeld, Sarah, Schwarz, Nicole, Denecke, Bernd, Jahr, Holger, Dreymueller, Daniela, Jankowski, Joachim, Ludwig, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
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Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741606/
https://ncbi.nlm.nih.gov/pubmed/26378057
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