Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

Pancreatic ductal adenocarcinoma (PDAC) cells utilize a novel non-canonical pathway of glutamine metabolism that is essential for tumor growth and redox balance. Inhibition of this metabolic pathway in PDAC can potentially synergize with therapies that increase intracellular reactive oxygen species...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Doudou, Fu, Zhiqiang, Chen, Ruiwan, Zhao, Xiaohui, Zhou, Yu, Zeng, Bing, Yu, Min, Zhou, Quanbo, Lin, Qing, Gao, Wenchao, Ye, Huilin, Zhou, Jiajia, Li, Zhihua, Liu, Yimin, Chen, Rufu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741594/
https://ncbi.nlm.nih.gov/pubmed/26439804
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