Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells

Neurocognitive deficits are serious sequelae that follow cranial irradiation used to treat patients with medulloblastoma and other brain neoplasms. Cranial irradiation causes apoptosis in the subgranular zone of the hippocampus leading to cognitive deficits. Valproic acid (VPA) treatment protected h...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Thotala, Dinesh, Karvas, Rowan M., Engelbach, John A., Garbow, Joel R., Hallahan, Andrew N., DeWees, Todd A., Laszlo, Andrei, Hallahan, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741505/
https://ncbi.nlm.nih.gov/pubmed/26413814
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