HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

BACKGROUND: Epithelial-mesenchymal transition (EMT) is a dedifferentiation process that mainly involves in mesenchymal marker upregulation, epithelial maker downregulation and cell polarity loss. Related hypoxia factors play a crucial role in EMT, however, it remains few evidence to clarify the role...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Yang, Jian, Zhang, Xu, Zhang, Yi, Zhu, Dongming, Zhang, Lifeng, Li, Ye, Zhu, Yanbo, Li, Dechun, Zhou, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741030/
https://ncbi.nlm.nih.gov/pubmed/26842802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0298-y
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