Joint mouse–human phenome-wide association to test gene function and disease risk

Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for ∼5 million sequence variants, and we compare our results to those extracted from a matched analysi...

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Publicado en:Nat Commun
Main Authors: Wang, Xusheng, Pandey, Ashutosh K., Mulligan, Megan K., Williams, Evan G., Mozhui, Khyobeni, Li, Zhengsheng, Jovaisaite, Virginija, Quarles, L. Darryl, Xiao, Zhousheng, Huang, Jinsong, Capra, John A., Chen, Zugen, Taylor, William L., Bastarache, Lisa, Niu, Xinnan, Pollard, Katherine S., Ciobanu, Daniel C., Reznik, Alexander O., Tishkov, Artem V., Zhulin, Igor B., Peng, Junmin, Nelson, Stanley F., Denny, Joshua C., Auwerx, Johan, Lu, Lu, Williams, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740880/
https://ncbi.nlm.nih.gov/pubmed/26833085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10464
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