Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions

Long noncoding RNAs (lncRNAs) regulate gene expression via their RNA product or through transcriptional interference, yet a strategy to differentiate these two processes is lacking. To address this, we used multiple small interfering RNAs (siRNAs) to silence GNG12-AS1, a nuclear lncRNA transcribed i...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Stojic, Lovorka, Niemczyk, Malwina, Orjalo, Arturo, Ito, Yoko, Ruijter, Anna Elisabeth Maria, Uribe-Lewis, Santiago, Joseph, Nimesh, Weston, Stephen, Menon, Suraj, Odom, Duncan T., Rinn, John, Gergely, Fanni, Murrell, Adele
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740813/
https://ncbi.nlm.nih.gov/pubmed/26832224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10406
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