A Dual Target-directed Agent against Interleukin-6 Receptor and Tumor Necrosis Factor α ameliorates experimental arthritis

A considerable proportion of patients with rheumatoid arthritis (RA) do not respond to monospecific agents. The purpose of our study was to generate a hybrid form of biologics, targeting tumor-necrosis factor alpha (TNFα) and interleukin-6 receptor (IL-6R), and determine its anti-arthritic propertie...

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Publicado en:Sci Rep
Autores principales: Kim, Youngkyun, Yi, Hyoju, Jung, Hyerin, Rim, Yeri Alice, Park, Narae, Kim, Juryun, Jung, Seung Min, Park, Sung-Hwan, Park, Young Woo, Ju, Ji Hyeon
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740770/
https://ncbi.nlm.nih.gov/pubmed/26841833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20150
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