Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis.
The conserved Asn-229 (N229) of thymidylate synthase (TS, EC 2.1.1.45) provides the only side chain that directly hydrogen bonds with the pyrimidine ring of the substrate dUMP. The carboxamide moiety forms a cyclic hydrogen bond network with the NH-3 and O-4 of the base and is a prime candidate for...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47406/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8378336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.18.8604 |
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